/dɪˈspeər/
the feeling that there is no hope and that you can do nothing to improve a difficult or worrying situation
  Lonely 
/ˈləʊnli/
sad because one has no... 
  Hurt
/həːt/
Cause pain or injury... 
  Depressed
/dɪˈprɛst/
depressed
(of a person)... 
  Guilty
/ˈɡɪlti/
conscious of, affected by, or... 
  Vulnerable
/ˈvʌln(ə)rəbl/
exposed to the...